How Does Osteoporosis Differ in Men and Women?

Osteoporosis in women,
for the most part, is related to the estrogen
change after menopause. For the most part. I mean, in general, if we
look at osteoporosis in women the most common cause is
post-menopausal osteoporosis. So there’s a shift in
estrogen, and estrogen itself affects bone balance. And when you lose that estrogen and you become post-menopausal, then what happens is that
the bone balance shifts. And again, you end up with
more loss than more gain. Sometimes, as much as the
gain and the peak bone mass that women achieve by
their 20s or even 18 to 25, what happens is that
they start losing that quite rapidly after menopause. In men, the theory isn’t clear. But it may be also related
to testosterone and androgen, where there’s a shift in hormone balance. But some of it may actually
be related to aging. There’s a whole new science of senescence or senescent cells in aging, which again would be
very complex to get into. But it’s trying to
understand what’s happening. And for the most part, there’s
a decoupling phenomenon between balance and the
hormonal overall homeostasis that happens in osteoporosis. It’s in both men and women. They are slightly different,
but they’re just as important.

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